It is hoped that this information will provide the reader with a better understanding of the rationale behind the aggregate proposed changes and the exciting developments in the upcoming edition. In this commentary, the authors highlight the overall organizational and structural changes as well as "what's new" in the Eighth Edition. The AJCC promulgates best staging practices through each new edition in an effort to provide cancer care providers with a powerful, knowledge-based resource for the battle against cancer. The editorial board viewed this iteration as a proactive effort to continue to build the important bridge from a "population-based" to a more "personalized" approach to patient classification, one that forms the conceptual framework and foundation of cancer staging in the era of precision molecular oncology. In the Eighth Edition of the AJCC Cancer Staging Manual, the goal of including relevant, nonanatomic (including molecular) factors has been foremost, although changes are made only when there is strong evidence for inclusion. The rapid evolution of knowledge in cancer biology and the discovery and validation of biologic factors that predict cancer outcome and response to treatment with better accuracy have led some cancer experts to question the utility of a TNM-based approach in clinical care at an individualized patient level. Many view the primary role of the tumor, lymph node, metastasis (TNM) system as that of a standardized classification system for evaluating cancer at a population level in terms of the extent of disease, both at initial presentation and after surgical treatment, and the overall impact of improvements in cancer treatment. The American Joint Committee on Cancer (AJCC) staging manual has become the benchmark for classifying patients with cancer, defining prognosis, and determining the best treatment approaches. 12 Medical Director, American Joint Committee on Cancer, Chicago, IL.11 Section Chief of Surgical Oncology and Professor of Surgery, University of Washington, Seattle, WA.10 Technical Specialist and Technical Editor, American Joint Committee on Cancer, Chicago, IL.9 Eighth Edition Project Manager and Managing Editor, American Joint Committee on Cancer, Chicago, IL.8 Radiation Oncologist, Greater Baltimore Medical Center, Baltimore, MD.7 Professor of Surgery and Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX.6 Professor of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.5 Chief Medical Officer, Complex Adaptive Systems Initiative, Arizona State University, Scottsdale, AZ.4 Professor of Oncology, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY. 3 Vice President, Healthcare Outcomes and Policy, Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY.2 Medical Director, Cancer Data Services, Levine Cancer Institute, Charlotte, NC.1 Professor and Chairman, UTHSC Gerwin Chair for Cancer Research, Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN.
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